Nephrology Board Review – Membranous Nephropathy

Mardi Gras Indian on Super Sunday. 2005. © Eric E. Simon

1.) How many histologic stages of Membranous Nephropathy are there?

A. 2

B. 3

C. 4

D. 5

2.) The stages correlate with the clinical manifestations of MN.

A. True

B. False

3.) Which of the following are podocyte antigens?

A. suPAR

B. Neutral endopeptidase (NEP)

C. Paxillin

D. Phospholipase A1 Receptor (PLA2R)

E. Both B and C

F. Both A and C

4.) Which type of Ig is most commonly found in the granular subepithelial deposits pathognomonically seen in idiopathic MN?

A. IgA

B. IgG1

C. IgM

D. IgG3

E. IgG4

5.) What treatment regimen would you recommend to a 34 year old male with idiopathic membranous proven by renal biopsy with 2 grams/day of proteinuria for the last 7 months with a serum creatinine of 1.1.

A. An alternating regimen of cyclophosphamide and glucocorticoids

B. An alternating regimen of chlorambucil and glucocorticoids

C. ACE-inhibitors and stains

D. A and C

E. B and C

Answers posted HERE.