1.) How many histologic stages of Membranous Nephropathy are there? A. 2 B. 3 C. 4 D. 5 Discussion: Four stages. Great LM and EM can be found here (AKJD Atlas). Stage I: Subepithelial deposits with little change to GBM, but extensive foot process effacement Stage II: Basement membrane “spikes” form between immune-complex Stage…
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1.) How many histologic stages of Membranous Nephropathy are there? A. 2 B. 3 C. 4 D. 5 2.) The stages correlate with the clinical manifestations of MN. A. True B. False 3.) Which of the following are podocyte antigens? A. suPAR B. Neutral endopeptidase (NEP) C. Paxillin D. Phospholipase A1 Receptor (PLA2R)…
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At the moment we don’t have clinically available serologic markers of disease activity for membranous nephropathy (PLA2R is in the pipeline) so we have to rely on clinical factors to predict prognosis. Above is a chart that lists the factors associated with Progression and strength of the associated (PPV). Source: Comprehensive Clinical Nephrology, 4th Edition.
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