Chloride Shunt

March 6, 2014

Here is a quick review of how the “chloride shunt” first described by Batlle et al in 1981 occurs. This can cause a voltage-dependent type of hyperkalemic distal renal tubular acidosis. In the cortical collecting duct, Na+ enters from the tubular lumen into the principal cell through the epithelial Na+ channel, ENaC. This electrogenic transport…
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